BRD-K44227013_ponatinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K44227013_ponatinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CALD1 caldesmon 1
CANX calnexin
CAV2 caveolin 2
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COPA coatomer protein complex, subunit alpha
CPD carboxypeptidase D
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXADR coxsackie virus and adenovirus receptor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF7 DDB1 and CUL4 associated factor 7
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPX3 glutathione peroxidase 3
HIPK1 homeodomain interacting protein kinase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
JUP junction plakoglobin
LBH limb bud and heart development
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMB microseminoprotein, beta-
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PKN2 protein kinase N2
PLEC plectin
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRKCI protein kinase C, iota
PSPH phosphoserine phosphatase
RAP2A RAP2A, member of RAS oncogene family
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC3 serine incorporator 3
SF1 splicing factor 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TNS3 tensin 3
TPR translocated promoter region, nuclear basket protein
TRAK2 trafficking protein, kinesin binding 2
TWF1 twinfilin actin binding protein 1
WAC WW domain containing adaptor with coiled-coil
YME1L1 YME1-like 1 ATPase
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ASRGL1 asparaginase like 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
C3ORF52 chromosome 3 open reading frame 52
CD200 CD200 molecule
CD47 CD47 molecule
DHRS2 dehydrogenase/reductase (SDR family) member 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
GAS7 growth arrest-specific 7
HOXC6 homeobox C6
IFI27 interferon, alpha-inducible protein 27
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LMCD1 LIM and cysteine-rich domains 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEG3 maternally expressed 3 (non-protein coding)
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
MSX1 msh homeobox 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGES prostaglandin E synthase
RHOBTB3 Rho-related BTB domain containing 3
RPIA ribose 5-phosphate isomerase A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TBX3 T-box 3
TLE4 transducin-like enhancer of split 4
TMEM176B transmembrane protein 176B
TRIM2 tripartite motif containing 2
ZDHHC11 zinc finger, DHHC-type containing 11