BRD-K44227013_ponatinib_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K44227013_ponatinib_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
ALDOA aldolase A, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GRB14 growth factor receptor-bound protein 14
HPRT1 hypoxanthine phosphoribosyltransferase 1
LINC00341 long intergenic non-protein coding RNA 341
MAL mal, T-cell differentiation protein
MBNL2 muscleblind-like splicing regulator 2
MPO myeloperoxidase
MTF2 metal response element binding transcription factor 2
NDRG2 NDRG family member 2
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PHGDH phosphoglycerate dehydrogenase
PLSCR3 phospholipid scramblase 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SFN stratifin
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TBC1D4 TBC1 domain family, member 4
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSPAN7 tetraspanin 7
VCAN versican
VSNL1 visinin-like 1
WDR61 WD repeat domain 61

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
APOE apolipoprotein E
BACE2 beta-site APP-cleaving enzyme 2
CGA glycoprotein hormones, alpha polypeptide
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
EFNB2 ephrin-B2
EGR3 early growth response 3
EPHA3 EPH receptor A3
FBXL12 F-box and leucine-rich repeat protein 12
FXYD3 FXYD domain containing ion transport regulator 3
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA6 GATA binding protein 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MANF mesencephalic astrocyte-derived neurotrophic factor
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
MUC4 mucin 4, cell surface associated
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOCS2 suppressor of cytokine signaling 2
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
TMC5 transmembrane channel-like 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)