BRD-K44227013_ponatinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K44227013_ponatinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
ASS1 argininosuccinate synthase 1
CAPN3 calpain 3, (p94)
CCNG1 cyclin G1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A1 collagen, type I, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISP3 cysteine-rich secretory protein 3
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
LCN2 lipocalin 2
LYZ lysozyme
MAGED1 melanoma antigen family D1
MFAP5 microfibrillar associated protein 5
MUC5B mucin 5B, oligomeric mucus/gel-forming
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PBLD phenazine biosynthesis-like protein domain containing
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS11 ribosomal protein S11
S100A14 S100 calcium binding protein A14
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC44A4 solute carrier family 44, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TCEAL4 transcription elongation factor A (SII)-like 4
TFF3 trefoil factor 3 (intestinal)
TSPAN8 tetraspanin 8
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AREG amphiregulin
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
LPL lipoprotein lipase
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSIP1 PC4 and SFRS1 interacting protein 1
RPIA ribose 5-phosphate isomerase A
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SORBS1 sorbin and SH3 domain containing 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)