BRD-K44227013_ponatinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K44227013_ponatinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAM28 ADAM metallopeptidase domain 28
ADAMDEC1 ADAM-like, decysin 1
ADI1 acireductone dioxygenase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP9A ATPase, class II, type 9A
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CDK19 cyclin-dependent kinase 19
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLU clusterin
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DUSP22 dual specificity phosphatase 22
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLG filaggrin
HBD hemoglobin, delta
HMOX1 heme oxygenase 1
HP haptoglobin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
JAG1 jagged 1
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LTBP1 latent transforming growth factor beta binding protein 1
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MYO10 myosin X
MYO5A myosin VA (heavy chain 12, myoxin)
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
RTN3 reticulon 3
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
TACC1 transforming, acidic coiled-coil containing protein 1
TATDN2 TatD DNase domain containing 2
TBL1X transducin (beta)-like 1X-linked
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADIRF adipogenesis regulatory factor
APOA1 apolipoprotein A-I
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX1 armadillo repeat containing, X-linked 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BPHL biphenyl hydrolase-like (serine hydrolase)
CCND2 cyclin D2
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN7 claudin 7
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DPH2 DPH2 homolog (S. cerevisiae)
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
G0S2 G0/G1 switch 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTT1 glutathione S-transferase theta 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
INA internexin neuronal intermediate filament protein, alpha
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD14 potassium channel tetramerization domain containing 14
KIF5C kinesin family member 5C
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LUM lumican
MCM10 minichromosome maintenance complex component 10
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPL57 mitochondrial ribosomal protein L57
MRPS30 mitochondrial ribosomal protein S30
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NEFH neurofilament, heavy polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NTS neurotensin
P4HB prolyl 4-hydroxylase, beta polypeptide
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PNKP polynucleotide kinase 3'-phosphatase
PPIC peptidylprolyl isomerase C (cyclophilin C)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
S100A13 S100 calcium binding protein A13
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRSF6 serine/arginine-rich splicing factor 6
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TBX3 T-box 3
TCTN1 tectonic family member 1
TMEM223 transmembrane protein 223
TMEM5 transmembrane protein 5
TOX3 TOX high mobility group box family member 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIP13 thyroid hormone receptor interactor 13
TUBB2B tubulin, beta 2B class IIb
VCAN versican