BRD-K44227013_ponatinib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K44227013_ponatinib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CNN1 calponin 1, basic, smooth muscle
CTBP2 C-terminal binding protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EGF epidermal growth factor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GPM6B glycoprotein M6B
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MATN2 matrilin 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNT nicotinamide nucleotide transhydrogenase
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUP210 nucleoporin 210kDa
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G16 phospholipase A2, group XVI
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCRG1 stimulator of chondrogenesis 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX11 SRY (sex determining region Y)-box 11
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADCK3 aarF domain containing kinase 3
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOA2 apolipoprotein A-II
APOD apolipoprotein D
BCL2A1 BCL2-related protein A1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C3 complement component 3
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
DOCK4 dedicator of cytokinesis 4
EFNB2 ephrin-B2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLA galactosidase, alpha
HOPX HOP homeobox
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LTBP2 latent transforming growth factor beta binding protein 2
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOK MOK protein kinase
NOP56 NOP56 ribonucleoprotein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PRPF4 pre-mRNA processing factor 4
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RELN reelin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRBP1 ribosome binding protein 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
TF transferrin
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TUBA4A tubulin, alpha 4a