BRD-K44100512_KIN001-043_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K44100512_KIN001-043_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ANXA10 annexin A10
ATF3 activating transcription factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUOX2 dual oxidase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM134B family with sequence similarity 134, member B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPX2 glutathione peroxidase 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ICAM2 intercellular adhesion molecule 2
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT20 keratin 20, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MME membrane metallo-endopeptidase
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SATB1 SATB homeobox 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
THBS1 thrombospondin 1
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BIK BCL2-interacting killer (apoptosis-inducing)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRLF1 cytokine receptor-like factor 1
EXOSC4 exosome component 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR4 fibroblast growth factor receptor 4
GPC3 glypican 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
NINJ2 ninjurin 2
NUSAP1 nucleolar and spindle associated protein 1
PDIA4 protein disulfide isomerase family A, member 4
PEG3 paternally expressed 3
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
SCGB2A1 secretoglobin, family 2A, member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAR steroidogenic acute regulatory protein
TIAM1 T-cell lymphoma invasion and metastasis 1
TTN titin
UGDH UDP-glucose 6-dehydrogenase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)