BRD-K44100512_KIN001-043_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K44100512_KIN001-043_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP4 bone morphogenetic protein 4
C1S complement component 1, s subcomponent
CCL2 chemokine (C-C motif) ligand 2
CD1E CD1e molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
EFNB2 ephrin-B2
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MTDH metadherin
NARFL nuclear prelamin A recognition factor-like
PITX1 paired-like homeodomain 1
PMP22 peripheral myelin protein 22
PRRC2C proline-rich coiled-coil 2C
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPRR1A small proline-rich protein 1A
SQRDL sulfide quinone reductase-like (yeast)
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN7 tetraspanin 7

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CGA glycoprotein hormones, alpha polypeptide
CKB creatine kinase, brain
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSPA2 heat shock 70kDa protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
MCAM melanoma cell adhesion molecule
MMD monocyte to macrophage differentiation-associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH1 notch 1
NXN nucleoredoxin
OBSL1 obscurin-like 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PIP prolactin-induced protein
PROM1 prominin 1
PRSS23 protease, serine, 23
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB15A thymosin beta 15a
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)