BRD-K44100512_KIN001-043_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K44100512_KIN001-043_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRA3 adhesion G protein-coupled receptor A3
AKR1C3 aldo-keto reductase family 1, member C3
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
BHLHE41 basic helix-loop-helix family, member e41
C1R complement component 1, r subcomponent
CCP110 centriolar coiled coil protein 110kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSK cathepsin K
CUX2 cut-like homeobox 2
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EREG epiregulin
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GPM6B glycoprotein M6B
IFT81 intraflagellar transport 81
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRP4 low density lipoprotein receptor-related protein 4
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCKSL1 MARCKS-like 1
MEX3D mex-3 RNA binding family member D
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
OLFM1 olfactomedin 1
PER3 period circadian clock 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLXNB2 plexin B2
PRSS3 protease, serine, 3
PTCH1 patched 1
RAB13 RAB13, member RAS oncogene family
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF144A ring finger protein 144A
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SEC63 SEC63 homolog (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SETBP1 SET binding protein 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TSC22D1 TSC22 domain family, member 1
USP6NL USP6 N-terminal like
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COCH cochlin
COX17 COX17 cytochrome c oxidase copper chaperone
CRYAB crystallin, alpha B
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOCK10 dedicator of cytokinesis 10
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD1 EH-domain containing 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JADE2 jade family PHD finger 2
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
LDLR low density lipoprotein receptor
LOX lysyl oxidase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6D lymphocyte antigen 6 complex, locus D
MINA MYC induced nuclear antigen
MIR22HG MIR22 host gene
MOK MOK protein kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
OAT ornithine aminotransferase
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA4 protein disulfide isomerase family A, member 4
PDZK1IP1 PDZK1 interacting protein 1
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTX3 pentraxin 3, long
RAB25 RAB25, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS4 regulator of G-protein signaling 4
S100A10 S100 calcium binding protein A10
SCGB2A2 secretoglobin, family 2A, member 2
SEC61G Sec61 gamma subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
STC2 stanniocalcin 2
TCL1A T-cell leukemia/lymphoma 1A
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3