BRD-K44100512_KIN001-043_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K44100512_KIN001-043_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
BAG2 BCL2-associated athanogene 2
BST2 bone marrow stromal cell antigen 2
CCL20 chemokine (C-C motif) ligand 20
CD69 CD69 molecule
CDA cytidine deaminase
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKC1 dyskeratosis congenita 1, dyskerin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPX2 glutathione peroxidase 2
HBEGF heparin-binding EGF-like growth factor
HOMER1 homer scaffolding protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LAPTM4B lysosomal protein transmembrane 4 beta
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP12 matrix metallopeptidase 12
PAEP progestagen-associated endometrial protein
PDGFC platelet derived growth factor C
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEK2 pleckstrin 2
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRKCH protein kinase C, eta
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
TACSTD2 tumor-associated calcium signal transducer 2
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMX2 thioredoxin-related transmembrane protein 2
TPST2 tyrosylprotein sulfotransferase 2
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARMCX1 armadillo repeat containing, X-linked 1
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK19 cyclin-dependent kinase 19
CHGB chromogranin B
COL1A2 collagen, type I, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CTBP2 C-terminal binding protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
ERBB2 erb-b2 receptor tyrosine kinase 2
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRB7 growth factor receptor-bound protein 7
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSPA2 heat shock 70kDa protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP7 insulin-like growth factor binding protein 7
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHDC2 kelch domain containing 2
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
NFIB nuclear factor I/B
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
RGS5 regulator of G-protein signaling 5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAP25 synaptosomal-associated protein, 25kDa
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TPPP3 tubulin polymerization-promoting protein family member 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2