BRD-K44100512_KIN001-043_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K44100512_KIN001-043_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
ANPEP alanyl (membrane) aminopeptidase
BAG2 BCL2-associated athanogene 2
CD44 CD44 molecule (Indian blood group)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CXCL14 chemokine (C-X-C motif) ligand 14
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FOSL1 FOS-like antigen 1
GPNMB glycoprotein (transmembrane) nmb
GRB14 growth factor receptor-bound protein 14
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
LUM lumican
N4BP2L2 NEDD4 binding protein 2-like 2
PCDH7 protocadherin 7
PHACTR2 phosphatase and actin regulator 2
PPIF peptidylprolyl isomerase F
RBP1 retinol binding protein 1, cellular
SACS sacsin molecular chaperone
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPR translocated promoter region, nuclear basket protein
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CD24 CD24 molecule
CFD complement factor D (adipsin)
CLDN3 claudin 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FCGBP Fc fragment of IgG binding protein
GAS1 growth arrest-specific 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MNDA myeloid cell nuclear differentiation antigen
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PON3 paraoxonase 3
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SGCE sarcoglycan, epsilon
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SYNM synemin, intermediate filament protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
USP18 ubiquitin specific peptidase 18
VSIG4 V-set and immunoglobulin domain containing 4