BRD-K44100512_KIN001-043_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K44100512_KIN001-043_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
BAMBI BMP and activin membrane-bound inhibitor
BMP4 bone morphogenetic protein 4
C8ORF4 chromosome 8 open reading frame 4
CANX calnexin
CARS cysteinyl-tRNA synthetase
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HGD homogentisate 1,2-dioxygenase
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
LAMP2 lysosomal-associated membrane protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
LARP1 La ribonucleoprotein domain family, member 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPXN leupaxin
LRRN3 leucine rich repeat neuronal 3
MID1IP1 MID1 interacting protein 1
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MTSS1 metastasis suppressor 1
MYO10 myosin X
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOV nephroblastoma overexpressed
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGD phosphogluconate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON2 paraoxonase 2
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RET ret proto-oncogene
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SEC63 SEC63 homolog (S. cerevisiae)
SELENBP1 selenium binding protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
STMN2 stathmin 2
SYT1 synaptotagmin I
TARS threonyl-tRNA synthetase
TDO2 tryptophan 2,3-dioxygenase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
VLDLR very low density lipoprotein receptor
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VSNL1 visinin-like 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
AXL AXL receptor tyrosine kinase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDCA3 cell division cycle associated 3
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
KRT17 keratin 17, type I
LHFP lipoma HMGIC fusion partner
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
MMP10 matrix metallopeptidase 10
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NDC80 NDC80 kinetochore complex component
NUSAP1 nucleolar and spindle associated protein 1
PDLIM4 PDZ and LIM domain 4
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS23 protease, serine, 23
PTRF polymerase I and transcript release factor
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon