BRD-K43782924_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K43782924_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
C1ORF54 chromosome 1 open reading frame 54
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
DUSP6 dual specificity phosphatase 6
F2R coagulation factor II (thrombin) receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GAL galanin/GMAP prepropeptide
GLS glutaminase
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GZMK granzyme K (granzyme 3; tryptase II)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1RL1 interleukin 1 receptor-like 1
IL32 interleukin 32
ITGA6 integrin, alpha 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NES nestin
RASIP1 Ras interacting protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRGN serglycin
STOM stomatin
TALDO1 transaldolase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
VWF von Willebrand factor
WEE1 WEE1 G2 checkpoint kinase
WWTR1 WW domain containing transcription regulator 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPA3 carboxypeptidase A3 (mast cell)
CST1 cystatin SN
CTSH cathepsin H
DCN decorin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM111A family with sequence similarity 111, member A
FAM65B family with sequence similarity 65, member B
FAM69A family with sequence similarity 69, member A
FASTKD5 FAST kinase domains 5
HMGB3 high mobility group box 3
HSPA1A heat shock 70kDa protein 1A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2C integral membrane protein 2C
KIF20A kinesin family member 20A
LTF lactotransferrin
MLPH melanophilin
MSMB microseminoprotein, beta-
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PLAC8 placenta-specific 8
REEP1 receptor accessory protein 1
RPS11 ribosomal protein S11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT6 septin 6
SORD sorbitol dehydrogenase
SPINK5 serine peptidase inhibitor, Kazal type 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM14A transmembrane protein 14A
TSPAN8 tetraspanin 8