BRD-K43682718_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K43682718_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BPHL biphenyl hydrolase-like (serine hydrolase)
CD24 CD24 molecule
CHI3L2 chitinase 3-like 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL11 chemokine (C-X-C motif) ligand 11
FAM129A family with sequence similarity 129, member A
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
HOPX HOP homeobox
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF5B kinesin family member 5B
KRT6B keratin 6B, type II
LGALS8 lectin, galactoside-binding, soluble, 8
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NINJ2 ninjurin 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PERP PERP, TP53 apoptosis effector
PLA2G16 phospholipase A2, group XVI
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR3 phospholipid scramblase 3
PPARD peroxisome proliferator-activated receptor delta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS2 regulator of G-protein signaling 2
S100A14 S100 calcium binding protein A14
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPT6 septin 6
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX11 SRY (sex determining region Y)-box 11
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C8ORF4 chromosome 8 open reading frame 4
CCND1 cyclin D1
CHD1 chromodomain helicase DNA binding protein 1
COPS7A COP9 signalosome subunit 7A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHC1 EF-hand domain (C-terminal) containing 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS1 fatty acid desaturase 1
FAM13B family with sequence similarity 13, member B
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
PIR pirin (iron-binding nuclear protein)
PRDX2 peroxiredoxin 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
S100P S100 calcium binding protein P
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
TXNL4B thioredoxin-like 4B
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VEZF1 vascular endothelial zinc finger 1
ZC3H13 zinc finger CCCH-type containing 13