BRD-K43389698_BMS-387032_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K43389698_BMS-387032_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
CHRDL1 chordin-like 1
DBT dihydrolipoamide branched chain transacylase E2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FXYD1 FXYD domain containing ion transport regulator 1
HLA-C major histocompatibility complex, class I, C
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGA6 integrin, alpha 6
ITM2C integral membrane protein 2C
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
LAPTM4B lysosomal protein transmembrane 4 beta
LARS leucyl-tRNA synthetase
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
MT1M metallothionein 1M
NMU neuromedin U
PF4 platelet factor 4
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
CADM1 cell adhesion molecule 1
CANT1 calcium activated nucleotidase 1
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLP1 cleavage and polyadenylation factor I subunit 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FBXL14 F-box and leucine-rich repeat protein 14
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBB inhibin, beta B
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KAZN kazrin, periplakin interacting protein
KLK10 kallikrein-related peptidase 10
KRT7 keratin 7, type II
MAT2A methionine adenosyltransferase II, alpha
MFSD5 major facilitator superfamily domain containing 5
MIEF1 mitochondrial elongation factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PALLD palladin, cytoskeletal associated protein
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PROM1 prominin 1
RPP38 ribonuclease P/MRP 38kDa subunit
S100A9 S100 calcium binding protein A9
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF22 zinc finger protein 22