BRD-K43389698_BMS-387032_SKBR3_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K43389698_BMS-387032_SKBR3_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIF1 allograft inflammatory factor 1
AK1 adenylate kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD300A CD300a molecule
CD59 CD59 molecule, complement regulatory protein
CP ceruloplasmin (ferroxidase)
CXADR coxsackie virus and adenovirus receptor
CYBA cytochrome b-245, alpha polypeptide
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EHBP1L1 EH domain binding protein 1-like 1
EIF5A eukaryotic translation initiation factor 5A
EML3 echinoderm microtubule associated protein like 3
EXOSC4 exosome component 4
FBN2 fibrillin 2
FECH ferrochelatase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAL galanin/GMAP prepropeptide
GPX3 glutathione peroxidase 3
HMGA1 high mobility group AT-hook 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MYO1B myosin IB
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NTS neurotensin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGK1 phosphoglycerate kinase 1
PLS3 plastin 3
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSENEN presenilin enhancer gamma secretase subunit
PYCARD PYD and CARD domain containing
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT5 sirtuin 5
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TPGS2 tubulin polyglutamylase complex subunit 2
TWF1 twinfilin actin binding protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
WFDC2 WAP four-disulfide core domain 2
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
ANXA3 annexin A3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CCNF cyclin F
CCNG2 cyclin G2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CPE carboxypeptidase E
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPT dermatopontin
EGR2 early growth response 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXO5 F-box protein 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GREB1 growth regulation by estrogen in breast cancer 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
HNMT histamine N-methyltransferase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OGN osteoglycin
PDGFRL platelet-derived growth factor receptor-like
PLAGL2 pleiomorphic adenoma gene-like 2
PMM2 phosphomannomutase 2
PNMA1 paraneoplastic Ma antigen 1
PPL periplakin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP2B RAP2B, member of RAS oncogene family
RCOR1 REST corepressor 1
RNF19B ring finger protein 19B
RYBP RING1 and YY1 binding protein
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SSBP2 single-stranded DNA binding protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TBPL1 TBP-like 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
USP6NL USP6 N-terminal like
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2