BRD-K43389698_BMS-387032_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

261 genes differentially expressed following the BRD-K43389698_BMS-387032_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AIF1 allograft inflammatory factor 1
AKAP8 A kinase (PRKA) anchor protein 8
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CCL21 chemokine (C-C motif) ligand 21
CCL8 chemokine (C-C motif) ligand 8
CHERP calcium homeostasis endoplasmic reticulum protein
CLEC3B C-type lectin domain family 3, member B
CLEC4A C-type lectin domain family 4, member A
CLIC2 chloride intracellular channel 2
CLU clusterin
CR2 complement component (3d/Epstein Barr virus) receptor 2
CREB5 cAMP responsive element binding protein 5
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSE dermatan sulfate epimerase
DUSP14 dual specificity phosphatase 14
EDN1 endothelin 1
EFNB2 ephrin-B2
EIF1 eukaryotic translation initiation factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FMO1 flavin containing monooxygenase 1
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FRS2 fibroblast growth factor receptor substrate 2
GADD45B growth arrest and DNA-damage-inducible, beta
GIMAP4 GTPase, IMAP family member 4
GIMAP6 GTPase, IMAP family member 6
GLS glutaminase
GMPR guanosine monophosphate reductase
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
LAMP1 lysosomal-associated membrane protein 1
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METTL7A methyltransferase like 7A
MICB MHC class I polypeptide-related sequence B
MMP10 matrix metallopeptidase 10
MT1E metallothionein 1E
NOLC1 nucleolar and coiled-body phosphoprotein 1
NXN nucleoredoxin
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA1 paraneoplastic Ma antigen 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASA4 RAS p21 protein activator 4
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF11 ring finger protein 11
RNMT RNA (guanine-7-) methyltransferase
RRAD Ras-related associated with diabetes
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SMIM7 small integral membrane protein 7
SNN stannin
STAB1 stabilin 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM14B transmembrane protein 14B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
UQCRH ubiquinol-cytochrome c reductase hinge protein
VWF von Willebrand factor
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274
ZNF304 zinc finger protein 304
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADAM10 ADAM metallopeptidase domain 10
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPH aspartate beta-hydroxylase
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C16ORF45 chromosome 16 open reading frame 45
C3ORF14 chromosome 3 open reading frame 14
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKAP4 cytoskeleton-associated protein 4
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COMMD3 COMM domain containing 3
CP ceruloplasmin (ferroxidase)
CYB5R2 cytochrome b5 reductase 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DES desmin
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECD ecdysoneless homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FAM111A family with sequence similarity 111, member A
FAM208A family with sequence similarity 208, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GSTA4 glutathione S-transferase alpha 4
GTPBP8 GTP-binding protein 8 (putative)
GYG1 glycogenin 1
HMGB1 high mobility group box 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
KRT15 keratin 15, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LTF lactotransferrin
LUM lumican
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MB myoglobin
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MEIS1 Meis homeobox 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYO1B myosin IB
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOTCH2NL notch 2 N-terminal like
NRIP3 nuclear receptor interacting protein 3
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDS5A PDS5 cohesin associated factor A
PDZRN3 PDZ domain containing ring finger 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PURA purine-rich element binding protein A
RAB15 RAB15, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLN sarcolipin
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS1 sorbin and SH3 domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SPTSSA serine palmitoyltransferase, small subunit A
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
SVIL supervillin
SYNM synemin, intermediate filament protein
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
UBA1 ubiquitin-like modifier activating enzyme 1
VCAN versican
VRK1 vaccinia related kinase 1
WDR6 WD repeat domain 6
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF638 zinc finger protein 638