BRD-K43389698_BMS-387032_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K43389698_BMS-387032_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
BACE2 beta-site APP-cleaving enzyme 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C9ORF16 chromosome 9 open reading frame 16
CCL20 chemokine (C-C motif) ligand 20
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CSF1R colony stimulating factor 1 receptor
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DPT dermatopontin
E2F2 E2F transcription factor 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KLHL24 kelch-like family member 24
LAMP3 lysosomal-associated membrane protein 3
LOC100272216 uncharacterized LOC100272216
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MXRA5 matrix-remodelling associated 5
NPTX2 neuronal pentraxin II
PARP8 poly (ADP-ribose) polymerase family, member 8
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PLLP plasmolipin
PLVAP plasmalemma vesicle associated protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
SYNGR2 synaptogyrin 2
TF transferrin
TMEM14B transmembrane protein 14B
TMEM231 transmembrane protein 231
TMSB15A thymosin beta 15a
TYROBP TYRO protein tyrosine kinase binding protein
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADRB2 adrenoceptor beta 2, surface
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARF6 ADP-ribosylation factor 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP55 centrosomal protein 55kDa
CHPT1 choline phosphotransferase 1
CNN3 calponin 3, acidic
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
FOSL1 FOS-like antigen 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
GLDC glycine dehydrogenase (decarboxylating)
H1F0 H1 histone family, member 0
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LASP1 LIM and SH3 protein 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NOTCH2 notch 2
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNPS1 RNA binding protein S1, serine-rich domain
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPP1 secreted phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TUBB6 tubulin, beta 6 class V
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCAN versican
WDR1 WD repeat domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1