BRD-K43389698_BMS-387032_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K43389698_BMS-387032_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATXN1 ataxin 1
BACE2 beta-site APP-cleaving enzyme 2
BHLHE40 basic helix-loop-helix family, member e40
CALD1 caldesmon 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFI complement factor I
CKB creatine kinase, brain
CLU clusterin
COCH cochlin
COL9A3 collagen, type IX, alpha 3
COLEC12 collectin sub-family member 12
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSL cathepsin L
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCTD dCMP deaminase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DYNLT3 dynein, light chain, Tctex-type 3
EGR1 early growth response 1
EGR3 early growth response 3
ENOSF1 enolase superfamily member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP1 guanylate binding protein 1, interferon-inducible
GHR growth hormone receptor
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
GUK1 guanylate kinase 1
HBE1 hemoglobin, epsilon 1
HEG1 heart development protein with EGF-like domains 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLF hepatic leukemia factor
HPRT1 hypoxanthine phosphoribosyltransferase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MFAP2 microfibrillar-associated protein 2
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NENF neudesin neurotrophic factor
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCCB propionyl CoA carboxylase, beta polypeptide
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLS3 plastin 3
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RABGAP1L RAB GTPase activating protein 1-like
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSAD2 radical S-adenosyl methionine domain containing 2
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCP2 sterol carrier protein 2
SDC2 syndecan 2
SEH1L SEH1-like (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNX10 sorting nexin 10
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
STXBP2 syntaxin binding protein 2
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
THBS4 thrombospondin 4
TMSB15A thymosin beta 15a
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN7 tetraspanin 7
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP7 vesicle-associated membrane protein 7
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
C20ORF24 chromosome 20 open reading frame 24
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CLTC clathrin, heavy chain (Hc)
CPA3 carboxypeptidase A3 (mast cell)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTBP2 C-terminal binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DRAM1 DNA-damage regulated autophagy modulator 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITPKB inositol-trisphosphate 3-kinase B
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
LMNB1 lamin B1
LUM lumican
LYZ lysozyme
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MSL1 male-specific lethal 1 homolog (Drosophila)
MYLK myosin light chain kinase
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNA proliferating cell nuclear antigen
PDPN podoplanin
PEG10 paternally expressed 10
POU2AF1 POU class 2 associating factor 1
PUF60 poly-U binding splicing factor 60KDa
RAB4A RAB4A, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM38 RNA binding motif protein 38
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC38A2 solute carrier family 38, member 2
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF12 transcription factor 12
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC3 trafficking protein particle complex 3
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
USP1 ubiquitin specific peptidase 1
WIPF1 WAS/WASL interacting protein family, member 1
XBP1 X-box binding protein 1