BRD-K43389698_BMS-387032_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-K43389698_BMS-387032_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AOX1 aldehyde oxidase 1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BTG2 BTG family, member 2
C3 complement component 3
C7 complement component 7
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CREB1 cAMP responsive element binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPR3 formyl peptide receptor 3
FRY furry homolog (Drosophila)
FYB FYN binding protein
FZD5 frizzled class receptor 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GHR growth hormone receptor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC4 glypican 4
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ITM2C integral membrane protein 2C
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF5C kinesin family member 5C
KNG1 kininogen 1
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMP3 lysosomal-associated membrane protein 3
LST1 leukocyte specific transcript 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NCF2 neutrophil cytosolic factor 2
NINJ2 ninjurin 2
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OSBPL8 oxysterol binding protein-like 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE9A phosphodiesterase 9A
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLLP plasmolipin
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
RAB17 RAB17, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS10 regulator of G-protein signaling 10
RNF130 ring finger protein 130
RNF43 ring finger protein 43
RPL31 ribosomal protein L31
RSAD2 radical S-adenosyl methionine domain containing 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAP2 signal transducing adaptor family member 2
SYNGR2 synaptogyrin 2
TCTN1 tectonic family member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52L1 tumor protein D52-like 1
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VAV3 vav 3 guanine nucleotide exchange factor
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ASCC3 activating signal cointegrator 1 complex subunit 3
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLTA clathrin, light chain A
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FBL fibrillarin
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLOD4 glyoxalase domain containing 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
JAK1 Janus kinase 1
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MKI67 marker of proliferation Ki-67
MYO10 myosin X
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TP53BP1 tumor protein p53 binding protein 1
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR4 ubiquitin protein ligase E3 component n-recognin 4
USP22 ubiquitin specific peptidase 22
VCP valosin containing protein
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZIC1 Zic family member 1