BRD-K43389698_BMS-387032_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

245 genes differentially expressed following the BRD-K43389698_BMS-387032_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANK2 ankyrin 2, neuronal
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BAALC brain and acute leukemia, cytoplasmic
BMP2 bone morphogenetic protein 2
CALCA calcitonin-related polypeptide alpha
CCL20 chemokine (C-C motif) ligand 20
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFI complement factor I
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DSP desmoplakin
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F8 coagulation factor VIII, procoagulant component
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GAP43 growth associated protein 43
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
HBEGF heparin-binding EGF-like growth factor
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
JAG1 jagged 1
JUN jun proto-oncogene
KDR kinase insert domain receptor
KIF5C kinesin family member 5C
KRT6A keratin 6A, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MCTP1 multiple C2 domains, transmembrane 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER2 period circadian clock 2
PHACTR1 phosphatase and actin regulator 1
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLP1 proteolipid protein 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRNP prion protein
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
PTN pleiotrophin
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB2A RAB2A, member RAS oncogene family
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REEP5 receptor accessory protein 5
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SKP1 S-phase kinase-associated protein 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TENM1 teneurin transmembrane protein 1
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF136 zinc finger protein 136
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK1 adenylate kinase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ATG3 autophagy related 3
AURKA aurora kinase A
BLMH bleomycin hydrolase
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC6 cell division cycle 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DND1 DND microRNA-mediated repression inhibitor 1
DNM1L dynamin 1-like
EAPP E2F-associated phosphoprotein
ECT2 epithelial cell transforming 2
FANCI Fanconi anemia, complementation group I
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRB7 growth factor receptor-bound protein 7
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LUM lumican
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MRPL12 mitochondrial ribosomal protein L12
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE4 transducin-like enhancer of split 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XBP1 X-box binding protein 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)