BRD-K43389698_BMS-387032_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

292 genes differentially expressed following the BRD-K43389698_BMS-387032_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ANKRD11 ankyrin repeat domain 11
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC2 baculoviral IAP repeat containing 2
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CA11 carbonic anhydrase XI
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD93 CD93 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CFI complement factor I
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHPF chondroitin polymerizing factor
CLEC11A C-type lectin domain family 11, member A
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DEFA4 defensin, alpha 4, corticostatin
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTT1 glutathione S-transferase theta 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IRF8 interferon regulatory factor 8
ITFG1 integrin alpha FG-GAP repeat containing 1
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0907 KIAA0907
LAMP2 lysosomal-associated membrane protein 2
LAPTM5 lysosomal protein transmembrane 5
LPPR4 lipid phosphate phosphatase-related protein type 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MCL1 myeloid cell leukemia 1
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MME membrane metallo-endopeptidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NCAN neurocan
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OLFM1 olfactomedin 1
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
PLAC8 placenta-specific 8
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLTP phospholipid transfer protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRO protein tyrosine phosphatase, receptor type, O
RAE1 ribonucleic acid export 1
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
TCTN1 tectonic family member 1
TFPI2 tissue factor pathway inhibitor 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF3 transmembrane 9 superfamily member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM231 transmembrane protein 231
TMEM45A transmembrane protein 45A
TRIM14 tripartite motif containing 14
TSPAN1 tetraspanin 1
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein
VSIG4 V-set and immunoglobulin domain containing 4
VWA5A von Willebrand factor A domain containing 5A
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BTG1 B-cell translocation gene 1, anti-proliferative
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFLAR CASP8 and FADD-like apoptosis regulator
CKS2 CDC28 protein kinase regulatory subunit 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
H1F0 H1 histone family, member 0
HDDC2 HD domain containing 2
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
LTF lactotransferrin
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MPST mercaptopyruvate sulfurtransferase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
NAV2 neuron navigator 2
NCOA1 nuclear receptor coactivator 1
NUSAP1 nucleolar and spindle associated protein 1
PDLIM4 PDZ and LIM domain 4
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDX radixin
RPS11 ribosomal protein S11
SFRP1 secreted frizzled-related protein 1
SGMS1 sphingomyelin synthase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SVIL supervillin
TBL1X transducin (beta)-like 1X-linked
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
VCAN versican
WDR6 WD repeat domain 6
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6