BRD-K43389698_BMS-387032_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K43389698_BMS-387032_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ALG8 ALG8, alpha-1,3-glucosyltransferase
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD36B ankyrin repeat domain 36B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL2L1 BCL2-like 1
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CERS6 ceramide synthase 6
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CLEC7A C-type lectin domain family 7, member A
COL11A1 collagen, type XI, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DMXL2 Dmx-like 2
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
EREG epiregulin
F12 coagulation factor XII (Hageman factor)
FAM13A family with sequence similarity 13, member A
FAM172A family with sequence similarity 172, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FST follistatin
GAGE3 G antigen 3
GC group-specific component (vitamin D binding protein)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MDFIC MyoD family inhibitor domain containing
MXRA7 matrix-remodelling associated 7
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
RELN reelin
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMYD2 SET and MYND domain containing 2
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TF transferrin
TGFB1 transforming growth factor, beta 1
TGOLN2 trans-golgi network protein 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM259 transmembrane protein 259
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
COA3 cytochrome c oxidase assembly factor 3
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFHD1 EF-hand domain family, member D1
ELF5 E74-like factor 5 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR2 fibroblast growth factor receptor 2
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP6 insulin-like growth factor binding protein 6
IGSF3 immunoglobulin superfamily, member 3
JUP junction plakoglobin
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
LPAR1 lysophosphatidic acid receptor 1
MALL mal, T-cell differentiation protein-like
MELK maternal embryonic leucine zipper kinase
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MYO1E myosin IE
MYOF myoferlin
NET1 neuroepithelial cell transforming 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PUF60 poly-U binding splicing factor 60KDa
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNPS1 RNA binding protein S1, serine-rich domain
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SLPI secretory leukocyte peptidase inhibitor
SOBP sine oculis binding protein homolog (Drosophila)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE4 transducin-like enhancer of split 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
VCP valosin containing protein
VGLL1 vestigial-like family member 1
WDR82 WD repeat domain 82