BRD-K43389698_BMS-387032_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-K43389698_BMS-387032_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOB apolipoprotein B
APOC2 apolipoprotein C-II
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C3 complement component 3
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDO1 cysteine dioxygenase type 1
CFB complement factor B
CFI complement factor I
CHERP calcium homeostasis endoplasmic reticulum protein
CLDN8 claudin 8
CLEC3B C-type lectin domain family 3, member B
COL15A1 collagen, type XV, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GHR growth hormone receptor
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HHEX hematopoietically expressed homeobox
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KRT23 keratin 23, type I
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK13 mitogen-activated protein kinase 13
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NCAM1 neural cell adhesion molecule 1
NME5 NME/NM23 family member 5
NMT2 N-myristoyltransferase 2
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
OPTN optineurin
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PER2 period circadian clock 2
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
SAMD4A sterile alpha motif domain containing 4A
SATB1 SATB homeobox 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TMOD1 tropomodulin 1
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRIP1 cysteine-rich protein 1 (intestinal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
ECT2 epithelial cell transforming 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBL fibrillarin
FKBP11 FK506 binding protein 11, 19 kDa
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GTPBP8 GTP-binding protein 8 (putative)
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
LXN latexin
MAP7 microtubule-associated protein 7
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYO10 myosin X
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRUNE2 prune homolog 2 (Drosophila)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYGB phosphorylase, glycogen; brain
RAB4A RAB4A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RPP25 ribonuclease P/MRP 25kDa subunit
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SLC38A2 solute carrier family 38, member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
TSPYL5 TSPY-like 5
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XBP1 X-box binding protein 1
XPO7 exportin 7