BRD-K43389675_DAUNORUBICIN_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

378 genes differentially expressed following the BRD-K43389675_DAUNORUBICIN_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APLP2 amyloid beta (A4) precursor-like protein 2
BEX4 brain expressed, X-linked 4
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CD24 CD24 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH13 cadherin 13
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLEC11A C-type lectin domain family 11, member A
CLIC3 chloride intracellular channel 3
CLIC5 chloride intracellular channel 5
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FCHO1 FCH domain only 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GMPR guanosine monophosphate reductase
GNLY granulysin
GRN granulin
HEG1 heart development protein with EGF-like domains 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1462 KIAA1462
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MXRA7 matrix-remodelling associated 7
NID1 nidogen 1
NUCB1 nucleobindin 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLD3 phospholipase D family, member 3
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCI protein kinase C, iota
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
STC1 stanniocalcin 1
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYNGR1 synaptogyrin 1
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACACA acetyl-CoA carboxylase alpha
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1A anti-silencing function 1A histone chaperone
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BLMH bleomycin hydrolase
BMI1 BMI1 proto-oncogene, polycomb ring finger
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAB39 calcium binding protein 39
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CELF1 CUGBP, Elav-like family member 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP170 centrosomal protein 170kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CNOT4 CCR4-NOT transcription complex, subunit 4
COASY CoA synthase
CRTC3 CREB regulated transcription coactivator 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
DAPK1 death-associated protein kinase 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
EIF4A3 eukaryotic translation initiation factor 4A3
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FA2H fatty acid 2-hydroxylase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM134C family with sequence similarity 134, member C
FAM222B family with sequence similarity 222, member B
FEM1B fem-1 homolog b (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GGNBP2 gametogenetin binding protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLOD4 glyoxalase domain containing 4
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
HNRNPF heterogeneous nuclear ribonucleoprotein F
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LARP4 La ribonucleoprotein domain family, member 4
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MKI67 marker of proliferation Ki-67
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MTCL1 microtubule crosslinking factor 1
MTMR4 myotubularin related protein 4
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1E myosin IE
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NNMT nicotinamide N-methyltransferase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP43 nucleoporin 43kDa
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PUM1 pumilio RNA-binding family member 1
RAB11A RAB11A, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RAB22A RAB22A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RMI1 RecQ mediated genome instability 1
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
RUFY3 RUN and FYVE domain containing 3
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETX senataxin
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNUPN snurportin 1
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNRG synergin, gamma
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TEFM transcription elongation factor, mitochondrial
TESC tescalcin
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM251 transmembrane protein 251
TMEM97 transmembrane protein 97
TMF1 TATA element modulatory factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAF4 TNF receptor-associated factor 4
TRAPPC3 trafficking protein particle complex 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSPAN8 tetraspanin 8
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBAP2 ubiquitin associated protein 2
UBE2S ubiquitin-conjugating enzyme E2S
UBE2Z ubiquitin-conjugating enzyme E2Z
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
XPO1 exportin 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZC3H11A zinc finger CCCH-type containing 11A
ZC3H4 zinc finger CCCH-type containing 4
ZNHIT3 zinc finger, HIT-type containing 3