BRD-K43226598_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K43226598_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CALR calreticulin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
COCH cochlin
COL14A1 collagen, type XIV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GYPC glycophorin C (Gerbich blood group)
HBE1 hemoglobin, epsilon 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NES nestin
OSBPL10 oxysterol binding protein-like 10
PDE4B phosphodiesterase 4B, cAMP-specific
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PRAME preferentially expressed antigen in melanoma
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
RTN2 reticulon 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SV2A synaptic vesicle glycoprotein 2A
SYNM synemin, intermediate filament protein
TAC1 tachykinin, precursor 1
TBXA2R thromboxane A2 receptor
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC85B coiled-coil domain containing 85B
COL5A2 collagen, type V, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP3 dual specificity phosphatase 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
KCTD12 potassium channel tetramerization domain containing 12
KIAA0125 KIAA0125
KLF4 Kruppel-like factor 4 (gut)
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PHACTR2 phosphatase and actin regulator 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
RALGDS ral guanine nucleotide dissociation stimulator
SAC3D1 SAC3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TCF4 transcription factor 4
TNS3 tensin 3
TOX3 TOX high mobility group box family member 3