BRD-K42918627_GSK-2126458_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BCL10 B-cell CLL/lymphoma 10
BIRC3 baculoviral IAP repeat containing 3
BZW2 basic leucine zipper and W2 domains 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CTGF connective tissue growth factor
DRAM1 DNA-damage regulated autophagy modulator 1
EDN1 endothelin 1
EFNA1 ephrin-A1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
GSTM3 glutathione S-transferase mu 3 (brain)
HBP1 HMG-box transcription factor 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGLL monoglyceride lipase
NUPR1 nuclear protein, transcriptional regulator, 1
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RND3 Rho family GTPase 3
RPA3 replication protein A3, 14kDa
RPS27L ribosomal protein S27-like
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TES testin LIM domain protein
TOM1L1 target of myb1 (chicken)-like 1
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TSG101 tumor susceptibility 101
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
VIM vimentin
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AQP3 aquaporin 3 (Gill blood group)
CCND1 cyclin D1
CDC25A cell division cycle 25A
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A6 collagen, type IV, alpha 6
CRISP3 cysteine-rich secretory protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
EDNRA endothelin receptor type A
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JAG1 jagged 1
KLK5 kallikrein-related peptidase 5
KRT5 keratin 5, type II
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
MAT2A methionine adenosyltransferase II, alpha
MEIS2 Meis homeobox 2
MFAP4 microfibrillar-associated protein 4
NEO1 neogenin 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NKX3-1 NK3 homeobox 1
NRGN neurogranin (protein kinase C substrate, RC3)
PCP4 Purkinje cell protein 4
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PSCA prostate stem cell antigen
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
S100A12 S100 calcium binding protein A12
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM4 transglutaminase 4
TP63 tumor protein p63