BRD-K42918627_GSK-2126458_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBR3 carbonyl reductase 3
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSZ cathepsin Z
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPC4 glypican 4
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KAT6B K(lysine) acetyltransferase 6B
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
LAPTM5 lysosomal protein transmembrane 5
LOXL2 lysyl oxidase-like 2
LPL lipoprotein lipase
LYN LYN proto-oncogene, Src family tyrosine kinase
MEF2C myocyte enhancer factor 2C
MYO6 myosin VI
PDE4B phosphodiesterase 4B, cAMP-specific
PROM1 prominin 1
SECISBP2L SECIS binding protein 2-like
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SRGN serglycin
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
THEMIS2 thymocyte selection associated family member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP12 A kinase (PRKA) anchor protein 12
CCL19 chemokine (C-C motif) ligand 19
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CTPS1 CTP synthase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM46A family with sequence similarity 46, member A
FBLN5 fibulin 5
GATA2 GATA binding protein 2
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
MFAP4 microfibrillar-associated protein 4
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OGN osteoglycin
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PNMA1 paraneoplastic Ma antigen 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
TACC1 transforming, acidic coiled-coil containing protein 1
TEX10 testis expressed 10
TFF1 trefoil factor 1
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2