BRD-K42918627_GSK-2126458_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BPTF bromodomain PHD finger transcription factor
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CEP57 centrosomal protein 57kDa
CIRBP cold inducible RNA binding protein
CLDN10 claudin 10
CST1 cystatin SN
CYB5R1 cytochrome b5 reductase 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG2 desmoglein 2
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
KAT6B K(lysine) acetyltransferase 6B
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KIAA1324 KIAA1324
KIZ kizuna centrosomal protein
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LRRC1 leucine rich repeat containing 1
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
OFD1 oral-facial-digital syndrome 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLSCR3 phospholipid scramblase 3
PLTP phospholipid transfer protein
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QARS glutaminyl-tRNA synthetase
RAB9A RAB9A, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS10 regulator of G-protein signaling 10
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TMC5 transmembrane channel-like 5
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIM2 tripartite motif containing 2
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP9X ubiquitin specific peptidase 9, X-linked
VNN1 vanin 1
WDR45 WD repeat domain 45
ZFAND5 zinc finger, AN1-type domain 5
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
CKLF chemokine-like factor
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F2 E2F transcription factor 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GZMK granzyme K (granzyme 3; tryptase II)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HRASLS HRAS-like suppressor
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LMNB2 lamin B2
LRRC59 leucine rich repeat containing 59
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALT1 MALT1 paracaspase
MELK maternal embryonic leucine zipper kinase
MRPL19 mitochondrial ribosomal protein L19
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NCAM1 neural cell adhesion molecule 1
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM45A transmembrane protein 45A
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein