BRD-K42918627_GSK-2126458_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K42918627_GSK-2126458_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAM10 ADAM metallopeptidase domain 10
ADAM28 ADAM metallopeptidase domain 28
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
AKAP9 A kinase (PRKA) anchor protein 9
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ANXA4 annexin A4
APOD apolipoprotein D
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSH cathepsin H
DCN decorin
DIAPH2 diaphanous-related formin 2
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
JMJD1C jumonji domain containing 1C
JUP junction plakoglobin
KLF9 Kruppel-like factor 9
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MTSS1 metastasis suppressor 1
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM4 olfactomedin 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PFDN5 prefoldin subunit 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPL periplakin
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
RBKS ribokinase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF130 ring finger protein 130
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
SSFA2 sperm specific antigen 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VNN1 vanin 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK4 adenylate kinase 4
ATAD2 ATPase family, AAA domain containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF52 chromosome 3 open reading frame 52
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EXO1 exonuclease 1
FADS1 fatty acid desaturase 1
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLRX2 glutaredoxin 2
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HILPDA hypoxia inducible lipid droplet-associated
HSPA14 heat shock 70kDa protein 14
INSIG1 insulin induced gene 1
LRP4 low density lipoprotein receptor-related protein 4
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFL neurofilament, light polypeptide
NOP56 NOP56 ribonucleoprotein
ORC6 origin recognition complex, subunit 6
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBK PDZ binding kinase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMC3IP PSMC3 interacting protein
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZWINT ZW10 interacting kinetochore protein