BRD-K42918627_GSK-2126458_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1S complement component 1, s subcomponent
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CFD complement factor D (adipsin)
CHMP5 charged multivesicular body protein 5
COL11A1 collagen, type XI, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DPP4 dipeptidyl-peptidase 4
ESRP1 epithelial splicing regulatory protein 1
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
GCH1 GTP cyclohydrolase 1
GRHL2 grainyhead-like 2 (Drosophila)
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
KLF9 Kruppel-like factor 9
LOX lysyl oxidase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
MT1M metallothionein 1M
MYOF myoferlin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NUPR1 nuclear protein, transcriptional regulator, 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEX11A peroxisomal biogenesis factor 11 alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLI polymerase (DNA directed) iota
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD2 SMAD family member 2
SPARCL1 SPARC-like 1 (hevin)
TERT telomerase reverse transcriptase
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMOD1 tropomodulin 1
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNL1 thioredoxin-like 1
VAV3 vav 3 guanine nucleotide exchange factor
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
B3GNT1
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DKK3 dickkopf WNT signaling pathway inhibitor 3
EHD3 EH-domain containing 3
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FTO fat mass and obesity associated
GLS glutaminase
GLTP glycolipid transfer protein
HAT1 histone acetyltransferase 1
HCAR3 hydroxycarboxylic acid receptor 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KYNU kynureninase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAT2A methionine adenosyltransferase II, alpha
MMP7 matrix metallopeptidase 7
NIP7 NIP7, nucleolar pre-rRNA processing protein
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLIN3 perilipin 3
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POU2AF1 POU class 2 associating factor 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RSL1D1 ribosomal L1 domain containing 1
S100A9 S100 calcium binding protein A9
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNAP25 synaptosomal-associated protein, 25kDa
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TARBP1 TAR (HIV-1) RNA binding protein 1