BRD-K42918627_GSK-2126458_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

257 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CCNI cyclin I
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CDK19 cyclin-dependent kinase 19
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA2 chloride channel accessory 2
CRISP3 cysteine-rich secretory protein 3
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR137B G protein-coupled receptor 137B
GRN granulin
GSDMB gasdermin B
GSN gelsolin
GYPC glycophorin C (Gerbich blood group)
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MMP7 matrix metallopeptidase 7
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NCK2 NCK adaptor protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PABPC3 poly(A) binding protein, cytoplasmic 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF2 polycomb group ring finger 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
QARS glutaminyl-tRNA synthetase
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RGS10 regulator of G-protein signaling 10
RND3 Rho family GTPase 3
RPL15 ribosomal protein L15
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPS14P3 ribosomal protein S14 pseudogene 3
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYF2 SYF2 pre-mRNA-splicing factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ALDOC aldolase C, fructose-bisphosphate
ATAD2 ATPase family, AAA domain containing 2
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKB creatine kinase, brain
COL5A1 collagen, type V, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
CYCS cytochrome c, somatic
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HELLS helicase, lymphoid-specific
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAMP3 lysosomal-associated membrane protein 3
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NME1 NME/NM23 nucleoside diphosphate kinase 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGC progastricsin (pepsinogen C)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SQLE squalene epoxidase
SRM spermidine synthase
SSR1 signal sequence receptor, alpha
STIP1 stress-induced phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
THBS1 thrombospondin 1
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein