BRD-K42918627_GSK-2126458_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CENPU centromere protein U
CFD complement factor D (adipsin)
CFH complement factor H
CGA glycoprotein hormones, alpha polypeptide
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CRYAB crystallin, alpha B
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAL histidine ammonia-lyase
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MED13L mediator complex subunit 13-like
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
NFIL3 nuclear factor, interleukin 3 regulated
NPR3 natriuretic peptide receptor 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OSBPL1A oxysterol binding protein-like 1A
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHACTR2 phosphatase and actin regulator 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RELN reelin
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SAP30 Sin3A-associated protein, 30kDa
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SKAP2 src kinase associated phosphoprotein 2
SLC35F2 solute carrier family 35, member F2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
STAG2 stromal antigen 2
SYNE2 spectrin repeat containing, nuclear envelope 2
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
VAV3 vav 3 guanine nucleotide exchange factor
WWOX WW domain containing oxidoreductase
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDOB aldolase B, fructose-bisphosphate
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCND2 cyclin D2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDCP1 CUB domain containing protein 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CNN3 calponin 3, acidic
COL6A1 collagen, type VI, alpha 1
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FGFBP1 fibroblast growth factor binding protein 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
ITGA6 integrin, alpha 6
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNN pinin, desmosome associated protein
PODXL podocalyxin-like
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRRC2C proline-rich coiled-coil 2C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNAI2 snail family zinc finger 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQLE squalene epoxidase
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
THY1 Thy-1 cell surface antigen
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIB2 tribbles pseudokinase 2
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1