BRD-K42918627_GSK-2126458_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K42918627_GSK-2126458_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMACR alpha-methylacyl-CoA racemase
AMPD3 adenosine monophosphate deaminase 3
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COCH cochlin
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DBT dihydrolipoamide branched chain transacylase E2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMXL1 Dmx-like 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EID1 EP300 interacting inhibitor of differentiation 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAT1 FAT atypical cadherin 1
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MATN2 matrilin 2
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZF1 myeloid zinc finger 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
OFD1 oral-facial-digital syndrome 1
PDE4C phosphodiesterase 4C, cAMP-specific
PDGFD platelet derived growth factor D
PTEN phosphatase and tensin homolog
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RB1CC1 RB1-inducible coiled-coil 1
RPL31 ribosomal protein L31
SCAMP1 secretory carrier membrane protein 1
SECISBP2L SECIS binding protein 2-like
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SRGN serglycin
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAC WW domain containing adaptor with coiled-coil
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF160 zinc finger protein 160
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A2 collagen, type V, alpha 2
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DIO1 deiodinase, iodothyronine, type I
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
H2AFZ H2A histone family, member Z
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MRPS16 mitochondrial ribosomal protein S16
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLS3 plastin 3
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLPI secretory leukocyte peptidase inhibitor
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein