BRD-K42918627_GSK-2126458_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K42918627_GSK-2126458_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ATP9A ATPase, class II, type 9A
BCAS1 breast carcinoma amplified sequence 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRISP3 cysteine-rich secretory protein 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GATA2 GATA binding protein 2
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
LOC100272216 uncharacterized LOC100272216
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MOAP1 modulator of apoptosis 1
MVP major vault protein
NBR1 neighbor of BRCA1 gene 1
NFE2L1 nuclear factor, erythroid 2-like 1
NMRK1 nicotinamide riboside kinase 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTEN phosphatase and tensin homolog
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SYT17 synaptotagmin XVII
TFF3 trefoil factor 3 (intestinal)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WIF1 WNT inhibitory factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APOA1 apolipoprotein A-I
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CEP57 centrosomal protein 57kDa
CHEK2 checkpoint kinase 2
CPE carboxypeptidase E
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPA4L heat shock 70kDa protein 4-like
LBR lamin B receptor
LMNB1 lamin B1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NUP85 nucleoporin 85kDa
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
RAB20 RAB20, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SHCBP1 SHC SH2-domain binding protein 1
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SRM spermidine synthase
TFRC transferrin receptor
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein