BRD-K42918627_GSK-2126458_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K42918627_GSK-2126458_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ACAA2 acetyl-CoA acyltransferase 2
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
ARG2 arginase 2
AUTS2 autism susceptibility candidate 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRLF1 cytokine receptor-like factor 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYTL1 cytokine-like 1
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOXO1 forkhead box O1
GAS2 growth arrest-specific 2
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KDM3A lysine (K)-specific demethylase 3A
KRT14 keratin 14, type I
LITAF lipopolysaccharide-induced TNF factor
NOTCH2NL notch 2 N-terminal like
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SOX4 SRY (sex determining region Y)-box 4
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TLK1 tousled-like kinase 1
TSC22D3 TSC22 domain family, member 3
TUBA4A tubulin, alpha 4a
VLDLR very low density lipoprotein receptor
WEE1 WEE1 G2 checkpoint kinase
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOLD1 apolipoprotein L domain containing 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASRGL1 asparaginase like 1
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDH5 cadherin 5, type 2 (vascular endothelium)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP14 dual specificity phosphatase 14
EDN1 endothelin 1
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G6PD glucose-6-phosphate dehydrogenase
GREM1 gremlin 1, DAN family BMP antagonist
HHEX hematopoietically expressed homeobox
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAT2A methionine adenosyltransferase II, alpha
MNDA myeloid cell nuclear differentiation antigen
MTCL1 microtubule crosslinking factor 1
MX1 MX dynamin-like GTPase 1
NOP16 NOP16 nucleolar protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PI3 peptidase inhibitor 3, skin-derived
PODXL podocalyxin-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SQLE squalene epoxidase
SRSF1 serine/arginine-rich splicing factor 1
SSX1 synovial sarcoma, X breakpoint 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TUBB2A tubulin, beta 2A class IIa
VWF von Willebrand factor
WWC1 WW and C2 domain containing 1