BRD-K42918627_GSK-2126458_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K42918627_GSK-2126458_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK2 AHNAK nucleoprotein 2
BLNK B-cell linker
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CAST calpastatin
CDC25B cell division cycle 25B
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
DEFB1 defensin, beta 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
GBP2 guanylate binding protein 2, interferon-inducible
GRAMD3 GRAM domain containing 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL21 kelch-like family member 21
KRT15 keratin 15, type I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NAV2 neuron navigator 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PTN pleiotrophin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEPP1 selenoprotein P, plasma, 1
SIRT3 sirtuin 3
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TTC3 tetratricopeptide repeat domain 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANGPT1 angiopoietin 1
BCHE butyrylcholinesterase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCND2 cyclin D2
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DUSP14 dual specificity phosphatase 14
EDNRB endothelin receptor type B
FOLR1 folate receptor 1 (adult)
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
JMJD6 jumonji domain containing 6
LEF1 lymphoid enhancer-binding factor 1
LRRC59 leucine rich repeat containing 59
MAT2A methionine adenosyltransferase II, alpha
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYRF myelin regulatory factor
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PON3 paraoxonase 3
PRAME preferentially expressed antigen in melanoma
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERINC5 serine incorporator 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STMN2 stathmin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TDO2 tryptophan 2,3-dioxygenase
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)