BRD-K42918627_GSK-2126458_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K42918627_GSK-2126458_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
APOD apolipoprotein D
AREG amphiregulin
ARG1 arginase 1
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPRIN2 caprin family member 2
CBX7 chromobox homolog 7
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN2 chimerin 2
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLDN1 claudin 1
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
COBLL1 cordon-bleu WH2 repeat protein-like 1
COLEC11 collectin sub-family member 11
COMP cartilage oligomeric matrix protein
CREBL2 cAMP responsive element binding protein-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTGF connective tissue growth factor
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA4 EPH receptor A4
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM8A1 family with sequence similarity 8, member A1
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FNBP1 formin binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
FZD5 frizzled class receptor 5
GPM6A glycoprotein M6A
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HLF hepatic leukemia factor
HMGA2 high mobility group AT-hook 2
HMGN4 high mobility group nucleosomal binding domain 4
HOXD1 homeobox D1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS1 LIM and senescent cell antigen-like domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LXN latexin
LY75 lymphocyte antigen 75
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MMP13 matrix metallopeptidase 13
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
N4BP2L1 NEDD4 binding protein 2-like 1
NDN necdin, melanoma antigen (MAGE) family member
NDRG1 N-myc downstream regulated 1
NMRK1 nicotinamide riboside kinase 1
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARP8 poly (ADP-ribose) polymerase family, member 8
PDE9A phosphodiesterase 9A
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLCL1 phospholipase C-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCQ protein kinase C, theta
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA7 spermatogenesis associated 7
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST18 suppression of tumorigenicity 18, zinc finger
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM204 transmembrane protein 204
TMSB15A thymosin beta 15a
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC6 zinc finger, CCHC domain containing 6
ZFAND1 zinc finger, AN1-type domain 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALG8 ALG8, alpha-1,3-glucosyltransferase
ASCC3 activating signal cointegrator 1 complex subunit 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C20ORF24 chromosome 20 open reading frame 24
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EMP2 epithelial membrane protein 2
FDPS farnesyl diphosphate synthase
FEN1 flap structure-specific endonuclease 1
FUCA1 fucosidase, alpha-L- 1, tissue
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IARS isoleucyl-tRNA synthetase
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R2 interleukin 1 receptor, type II
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
MARS methionyl-tRNA synthetase
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
QPRT quinolinate phosphoribosyltransferase
RGS1 regulator of G-protein signaling 1
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TRIM16 tripartite motif containing 16
TUBG1 tubulin, gamma 1
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UCK2 uridine-cytidine kinase 2
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase