BRD-K42918627_GSK-2126458_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K42918627_GSK-2126458_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ADAM28 ADAM metallopeptidase domain 28
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNG1 cyclin G1
CCNI cyclin I
CFD complement factor D (adipsin)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
EDN3 endothelin 3
EGFR epidermal growth factor receptor
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF4B eukaryotic translation initiation factor 4B
EPHB2 EPH receptor B2
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
GBP2 guanylate binding protein 2, interferon-inducible
GPATCH8 G patch domain containing 8
GPR137B G protein-coupled receptor 137B
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LTA4H leukotriene A4 hydrolase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MXI1 MAX interactor 1, dimerization protein
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NONO non-POU domain containing, octamer-binding
NPC1 Niemann-Pick disease, type C1
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PAEP progestagen-associated endometrial protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RB1CC1 RB1-inducible coiled-coil 1
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RPL36 ribosomal protein L36
SDCBP syndecan binding protein (syntenin)
SERINC1 serine incorporator 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI2 tissue factor pathway inhibitor 2
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AQP3 aquaporin 3 (Gill blood group)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALR calreticulin
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS isoleucyl-tRNA synthetase
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA2 replication protein A2, 32kDa
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC2 structural maintenance of chromosomes 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPE small nuclear ribonucleoprotein polypeptide E
SRM spermidine synthase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMELESS timeless circadian clock
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein