BRD-K42918627_GSK-2126458_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K42918627_GSK-2126458_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C5 complement component 5
C9 complement component 9
CCND1 cyclin D1
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
ERBB3 erb-b2 receptor tyrosine kinase 3
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGL1 fibrinogen-like 1
FST follistatin
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSTZ1 glutathione S-transferase zeta 1
HAL histidine ammonia-lyase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGFBP1 insulin-like growth factor binding protein 1
LGALS8 lectin, galactoside-binding, soluble, 8
MUC5B mucin 5B, oligomeric mucus/gel-forming
OXTR oxytocin receptor
PAX8 paired box 8
PKP4 plakophilin 4
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
RNASET2 ribonuclease T2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SST somatostatin
TCF4 transcription factor 4
TNS3 tensin 3

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AREG amphiregulin
CDK4 cyclin-dependent kinase 4
CKS2 CDC28 protein kinase regulatory subunit 2
CSTA cystatin A (stefin A)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPB8 heat shock 22kDa protein 8
IFI44 interferon-induced protein 44
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KYNU kynureninase
LAMA3 laminin, alpha 3
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PTPRK protein tyrosine phosphatase, receptor type, K
RAD23B RAD23 homolog B (S. cerevisiae)
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFBI transforming growth factor, beta-induced, 68kDa
THAP11 THAP domain containing 11
TNC tenascin C
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein