BRD-K42918627_GSK-2126458_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K42918627_GSK-2126458_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BGN biglycan
CAMLG calcium modulating ligand
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETHE1 ethylmalonic encephalopathy 1
ETV1 ets variant 1
FANCL Fanconi anemia, complementation group L
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXO4 forkhead box O4
GALC galactosylceramidase
GBP2 guanylate binding protein 2, interferon-inducible
GDI1 GDP dissociation inhibitor 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8H golgin A8 family, member H
GSDMB gasdermin B
HAUS4 HAUS augmin-like complex, subunit 4
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS2 insulin receptor substrate 2
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0355 KIAA0355
KIZ kizuna centrosomal protein
LETMD1 LETM1 domain containing 1
LPAR6 lysophosphatidic acid receptor 6
LTA4H leukotriene A4 hydrolase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MFAP2 microfibrillar-associated protein 2
MFGE8 milk fat globule-EGF factor 8 protein
MMP2 matrix metallopeptidase 2
MPDZ multiple PDZ domain protein
MTMR11 myotubularin related protein 11
N4BP2L1 NEDD4 binding protein 2-like 1
NFIB nuclear factor I/B
NOX4 NADPH oxidase 4
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
PGLS 6-phosphogluconolactonase
PLAU plasminogen activator, urokinase
PLSCR4 phospholipid scramblase 4
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
VCAN versican
WDR19 WD repeat domain 19
WEE1 WEE1 G2 checkpoint kinase

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AK4 adenylate kinase 4
ALB albumin
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOC aldolase C, fructose-bisphosphate
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CALU calumenin
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKB creatine kinase, brain
COBLL1 cordon-bleu WH2 repeat protein-like 1
CRYAB crystallin, alpha B
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EGF epidermal growth factor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ENO1 enolase 1, (alpha)
FABP1 fatty acid binding protein 1, liver
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GLRX2 glutaredoxin 2
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
GSPT1 G1 to S phase transition 1
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
L1CAM L1 cell adhesion molecule
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINA MYC induced nuclear antigen
MSMO1 methylsterol monooxygenase 1
MTCH2 mitochondrial carrier 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA3 protein disulfide isomerase family A, member 3
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
QPRT quinolinate phosphoribosyltransferase
RCAN1 regulator of calcineurin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELT selenoprotein T
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
STIP1 stress-induced phosphoprotein 1
TARS threonyl-tRNA synthetase
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VDAC1 voltage-dependent anion channel 1
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase