BRD-K42918627_GSK-2126458_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K42918627_GSK-2126458_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX1 armadillo repeat containing, X-linked 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAST calpastatin
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CEP68 centrosomal protein 68kDa
CFB complement factor B
CHN2 chimerin 2
CPD carboxypeptidase D
CPE carboxypeptidase E
CREBL2 cAMP responsive element binding protein-like 2
CTSB cathepsin B
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FST follistatin
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MEF2C myocyte enhancer factor 2C
MKNK2 MAP kinase interacting serine/threonine kinase 2
MOAP1 modulator of apoptosis 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS3 nitric oxide synthase 3 (endothelial cell)
NPIPB3 nuclear pore complex interacting protein family, member B3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PGF placental growth factor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMEL premelanosome protein
PRAME preferentially expressed antigen in melanoma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
USP34 ubiquitin specific peptidase 34
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA10 annexin A10
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA2 carbonic anhydrase II
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CKLF chemokine-like factor
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CTSE cathepsin E
CTSZ cathepsin Z
CYB561 cytochrome b561
CYCS cytochrome c, somatic
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPI glucose-6-phosphate isomerase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0020 KIAA0020
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPHOSPH6 M-phase phosphoprotein 6
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL17 mitochondrial ribosomal protein L17
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NPR3 natriuretic peptide receptor 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
PGM1 phosphoglucomutase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTRF polymerase I and transcript release factor
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TMEM47 transmembrane protein 47
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein