BRD-K42918627_GSK-2126458_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-K42918627_GSK-2126458_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ANXA4 annexin A4
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BCAS1 breast carcinoma amplified sequence 1
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTF3 basic transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREBL2 cAMP responsive element binding protein-like 2
CTSK cathepsin K
CTSW cathepsin W
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF4B eukaryotic translation initiation factor 4B
ELOVL4 ELOVL fatty acid elongase 4
EPAS1 endothelial PAS domain protein 1
ETHE1 ethylmalonic encephalopathy 1
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GALC galactosylceramidase
GATAD1 GATA zinc finger domain containing 1
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MARCKS myristoylated alanine-rich protein kinase C substrate
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NCK1 NCK adaptor protein 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMRK1 nicotinamide riboside kinase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGLS 6-phosphogluconolactonase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCAMP1 secretory carrier membrane protein 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SST somatostatin
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM30B transmembrane protein 30B
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EXO1 exonuclease 1
EXOSC8 exosome component 8
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NUP107 nucleoporin 107kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCB protein kinase C, beta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein