BRD-K42918627_GSK-2126458_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K42918627_GSK-2126458_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
AGR2 anterior gradient 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ATP11B ATPase, class VI, type 11B
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAST calpastatin
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DOCK9 dedicator of cytokinesis 9
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
ETHE1 ethylmalonic encephalopathy 1
FAM13A family with sequence similarity 13, member A
FAM8A1 family with sequence similarity 8, member A1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
GBP2 guanylate binding protein 2, interferon-inducible
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KRT8 keratin 8, type II
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MTSS1 metastasis suppressor 1
MYOF myoferlin
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PLAU plasminogen activator, urokinase
PLSCR4 phospholipid scramblase 4
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PRAF2 PRA1 domain family, member 2
PROS1 protein S (alpha)
RSRP1 arginine/serine-rich protein 1
SDPR serum deprivation response
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSPN sarcospan
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TPM2 tropomyosin 2 (beta)
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELANE elastase, neutrophil expressed
EMX2 empty spiracles homeobox 2
EXO1 exonuclease 1
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HJURP Holliday junction recognition protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IL17RB interleukin 17 receptor B
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LMNB1 lamin B1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MSX1 msh homeobox 1
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUP107 nucleoporin 107kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein