BRD-K42918627_GSK-2126458_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K42918627_GSK-2126458_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ADCK3 aarF domain containing kinase 3
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA4 annexin A4
BTF3 basic transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DALRD3 DALR anticodon binding domain containing 3
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DST dystonin
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
ERBB3 erb-b2 receptor tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GREM1 gremlin 1, DAN family BMP antagonist
HBP1 HMG-box transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGHM immunoglobulin heavy constant mu
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDE4DIP phosphodiesterase 4D interacting protein
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLCB4 phospholipase C, beta 4
PLS3 plastin 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QARS glutaminyl-tRNA synthetase
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SERINC3 serine incorporator 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBD thrombomodulin
TMEM63A transmembrane protein 63A
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CSTA cystatin A (stefin A)
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HSPA1A heat shock 70kDa protein 1A
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MKI67 marker of proliferation Ki-67
MT1X metallothionein 1X
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PDHX pyruvate dehydrogenase complex, component X
PIP prolactin-induced protein
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSRC1 proline/serine-rich coiled-coil 1
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RBM38 RNA binding motif protein 38
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SESN1 sestrin 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein