BRD-K42728290_NVP-BGJ398_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K42728290_NVP-BGJ398_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1S complement component 1, s subcomponent
CD14 CD14 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CLDN4 claudin 4
CREB1 cAMP responsive element binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DAPK1 death-associated protein kinase 1
DICER1 dicer 1, ribonuclease type III
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
FMOD fibromodulin
FOXO1 forkhead box O1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
IGHA1 immunoglobulin heavy constant alpha 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
KIAA0125 KIAA0125
KIF5B kinesin family member 5B
KLF4 Kruppel-like factor 4 (gut)
KLHDC10 kelch domain containing 10
KRT18 keratin 18, type I
LGALS2 lectin, galactoside-binding, soluble, 2
MAGEB2 melanoma antigen family B2
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEST mesoderm specific transcript
MMP12 matrix metallopeptidase 12
MTSS1 metastasis suppressor 1
NCOA1 nuclear receptor coactivator 1
NDFIP1 Nedd4 family interacting protein 1
NFE2 nuclear factor, erythroid 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRAME preferentially expressed antigen in melanoma
PTRF polymerase I and transcript release factor
RHOA ras homolog family member A
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSU1 Ras suppressor protein 1
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIP6 thyroid hormone receptor interactor 6
TSPAN6 tetraspanin 6
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
YBX3 Y box binding protein 3
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCND1 cyclin D1
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP57 centrosomal protein 57kDa
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EI24 etoposide induced 2.4
GOLGA8A golgin A8 family, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
LPAR6 lysophosphatidic acid receptor 6
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDLIM4 PDZ and LIM domain 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAU plasminogen activator, urokinase
PSD3 pleckstrin and Sec7 domain containing 3
PYCARD PYD and CARD domain containing
RSRP1 arginine/serine-rich protein 1
S100A11 S100 calcium binding protein A11
SC5D sterol-C5-desaturase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1