BRD-K42693031_Glimepiride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K42693031_Glimepiride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAT2 acetyl-CoA acetyltransferase 2
ACPP acid phosphatase, prostate
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK14 cyclin-dependent kinase 14
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTX4 deltex 4, E3 ubiquitin ligase
EDNRA endothelin receptor type A
EXT1 exostosin glycosyltransferase 1
FAM13A family with sequence similarity 13, member A
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHOD3 formin homology 2 domain containing 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HIRA histone cell cycle regulator
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI44L interferon-induced protein 44-like
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1RN interleukin 1 receptor antagonist
IPO13 importin 13
IRF8 interferon regulatory factor 8
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT81 keratin 81, type II
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
ORC1 origin recognition complex, subunit 1
P3H2 prolyl 3-hydroxylase 2
PAPD7 PAP associated domain containing 7
PARM1 prostate androgen-regulated mucin-like protein 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POU2AF1 POU class 2 associating factor 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PYCARD PYD and CARD domain containing
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
STAP1 signal transducing adaptor family member 1
STEAP3 STEAP family member 3, metalloreductase
STS steroid sulfatase (microsomal), isozyme S
TFRC transferrin receptor
TMEM35 transmembrane protein 35
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA5 annexin A5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHPT1 choline phosphotransferase 1
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DYNLRB1 dynein, light chain, roadblock-type 1
ECI2 enoyl-CoA delta isomerase 2
FBLN5 fibulin 5
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HOXC10 homeobox C10
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
LAGE3 L antigen family, member 3
LYRM1 LYR motif containing 1
NFIB nuclear factor I/B
NPR3 natriuretic peptide receptor 3
PENK proenkephalin
PITRM1 pitrilysin metallopeptidase 1
PLEC plectin
RAD51C RAD51 paralog C
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
SACS sacsin molecular chaperone
SH3BP4 SH3-domain binding protein 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPRR2B small proline-rich protein 2B
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
STXBP2 syntaxin binding protein 2
TAC1 tachykinin, precursor 1
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOB1 transducer of ERBB2, 1
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)