BRD-K42499654_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K42499654_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
CTSB cathepsin B
CTSL cathepsin L
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0753 KIAA0753
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
MAP1B microtubule-associated protein 1B
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
NQO1 NAD(P)H dehydrogenase, quinone 1
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SQSTM1 sequestosome 1
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPST2 tyrosylprotein sulfotransferase 2
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
C7 complement component 7
CA12 carbonic anhydrase XII
CDK1 cyclin-dependent kinase 1
CFH complement factor H
COMMD8 COMM domain containing 8
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FBP1 fructose-1,6-bisphosphatase 1
GALC galactosylceramidase
GREB1 growth regulation by estrogen in breast cancer 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HOXC6 homeobox C6
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
ISOC1 isochorismatase domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MOAP1 modulator of apoptosis 1
MUC1 mucin 1, cell surface associated
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAPOLA poly(A) polymerase alpha
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PLBD1 phospholipase B domain containing 1
PLS1 plastin 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRSS23 protease, serine, 23
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCP2 sterol carrier protein 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPDEF SAM pointed domain containing ETS transcription factor
STS steroid sulfatase (microsomal), isozyme S
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase