BRD-K42499654_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K42499654_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
APOC1 apolipoprotein C-I
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CLEC5A C-type lectin domain family 5, member A
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DCN decorin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GBP2 guanylate binding protein 2, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IGKV4-1 immunoglobulin kappa variable 4-1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTA4H leukotriene A4 hydrolase
LY96 lymphocyte antigen 96
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NSG1 neuron specific gene family member 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGD phosphogluconate dehydrogenase
PXMP2 peroxisomal membrane protein 2, 22kDa
RPL10 ribosomal protein L10
S100A8 S100 calcium binding protein A8
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPRR1B small proline-rich protein 1B
SULF1 sulfatase 1
THBD thrombomodulin
TMEM45A transmembrane protein 45A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AREG amphiregulin
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CD44 CD44 molecule (Indian blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL4A5 collagen, type IV, alpha 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
FABP1 fatty acid binding protein 1, liver
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IL20RA interleukin 20 receptor, alpha
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS1 lectin, galactoside-binding, soluble, 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LXN latexin
LY75 lymphocyte antigen 75
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
NR2F1 nuclear receptor subfamily 2, group F, member 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RABGAP1L RAB GTPase activating protein 1-like
RGS5 regulator of G-protein signaling 5
SEPP1 selenoprotein P, plasma, 1
TACC1 transforming, acidic coiled-coil containing protein 1
TF transferrin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
UBE2E3 ubiquitin-conjugating enzyme E2E 3
ZBTB38 zinc finger and BTB domain containing 38