BRD-K42499654_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K42499654_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL9A2 collagen, type IX, alpha 2
CRISP3 cysteine-rich secretory protein 3
DCN decorin
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
KRT15 keratin 15, type I
LGALS8 lectin, galactoside-binding, soluble, 8
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP2 microfibrillar-associated protein 2
PAWR PRKC, apoptosis, WT1, regulator
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
APOLD1 apolipoprotein L domain containing 1
BACE2 beta-site APP-cleaving enzyme 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
CD24 CD24 molecule
CLINT1 clathrin interactor 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGF13 fibroblast growth factor 13
FKBP5 FK506 binding protein 5
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HOXA10 homeobox A10
IL6ST interleukin 6 signal transducer
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTS neurotensin
RPL36 ribosomal protein L36
SACS sacsin molecular chaperone
SH3BP4 SH3-domain binding protein 4
SMAD3 SMAD family member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TTC3 tetratricopeptide repeat domain 3
UGCG UDP-glucose ceramide glucosyltransferase