BRD-K42489623_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K42489623_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRB biliverdin reductase B
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPC1 glypican 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HEATR1 HEAT repeat containing 1
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC5B mucin 5B, oligomeric mucus/gel-forming
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRG1 neuregulin 1
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PGD phosphogluconate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
RGS2 regulator of G-protein signaling 2
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TKT transketolase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
CCNE2 cyclin E2
CFB complement factor B
CFH complement factor H
CHN2 chimerin 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAP fibroblast activation protein, alpha
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA5 homeobox A5
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC16A leucine rich repeat containing 16A
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
NMI N-myc (and STAT) interactor
PCOLCE procollagen C-endopeptidase enhancer
PROM1 prominin 1
PSPH phosphoserine phosphatase
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFRP4 secreted frizzled-related protein 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
STMN1 stathmin 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1
ZIC1 Zic family member 1